Progesterone offers no protection against miscarriages

Progesterone offers no protection against miscarriages

The risk of miscarriage through progesterone therapy was not reduced
The hormone progesterone has a major influence on the course of pregnancy. Use in women who have already had multiple miscarriages seemed obvious, and preparations have been available for decades to reduce the risk of miscarriage. However, the latest study by a research team led by Professor Arri Coomarasamy from the University of Birmingham comes to the conclusion that “progesterone therapy in the first third of pregnancy does not lead to a significantly higher rate of live births in women with a history of unexplained repeated miscarriages . "

Progesterone use cannot prevent another miscarriage in women who have had multiple miscarriages, according to the researchers' disappointing conclusion. The use of progesterone to secure the course of pregnancy with an increased risk of miscarriage is therefore pointless. However, the researchers cannot rule out the possibility of other positive effects. Professor Coomarasamy and colleagues write in the “New England Journal of Medicine” that no harmful effects were found.

Risk of miscarriage unchanged
836 pregnant women with previous unexplained repeated miscarriages participated in the five-year study. Of these, 404 women received "vaginal suppositories containing 400 milligrams of micronized progesterone" twice a day and 432 women received a suppository with placebo, the researchers explain. Treatment started immediately after the first positive urine pregnancy test (at the latest in the 6th week of pregnancy) and was continued until the end of the first trimester. In the study, the rate of live births was 65.8 percent (262 of 398 women) in the progesterone group and 63.3 percent (271 of 428 women) in the placebo group. Accordingly, there were no significant differences in the risk of miscarriage between the progesterone group and the placebo group.

Progesterone therapy does not meet expectations
"Like many other people, we hoped the study would confirm progesterone as an effective treatment," said Professor Arri Coomarasamy. This hope was not fulfilled. But although the results are disappointing, progesterone therapy can have other positive effects, such as "preventing miscarriage in women with early pregnancy bleeding." In addition, the study results also showed that progesterone treatment did not have any significant negative effects on women or their babies appeared, reports the University of Birmingham. (fp)

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